Copyright (C) 1995-2003, JVV
Cytochrome P450 is a family of the body's more powerful detox enzymes.
Over 60 key forms are known, with hundreds of genetic variations possible,
producing a wide variety of susceptibility to specific toxins.
As the saying goes, "One man's meat is another man's poison".
Problems with P450 are often involved in porphyria type disorders. P450 production may be inhibited or substantially used up by H2 blockers, some antacids, SSRI's (Prozac, Paxil, Zoloft, etc.,) and perhaps one fifth of all medications. In this manner, these drugs have the potential to worsen, or even create, a susceptibility to many common chemicals, and thus may trigger Multiple Chemical Sensitivities / Environmental Illness and related syndromes. The oddness of some of these symptoms may prompt some doctors to prescribe SSRI's, thus making the situation worse.
Long term inhibition of heme synthesis due to P450 insufficiency may cause anemia. This, and the resulting metabolic reductions, may cause reductions in the body's ability to maintain itself, showing up as a wide variety of health problems similar to those of Wilson's Syndrome, as well as behavioral and cognitive problems similar to those described in The Cold Body Page. A related detoxification pathway involves Paraoxonase and related oxonases.
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